According to the new requirement of sustainable development in the new stage, this paper puts forward the definition of the safeguarding capacity of regional sustainable development and uses some statistical methods of frequency statistics and principal component analysis to construct the index system of safeguarding capacity. Then it takes the data of the Three Gorges reservoir area for example to make empirical analysis, and provides efficient measurement tools to further measure the regional sustainability together with its safeguarding capacity, and therefore helps the government and the relevant organizations to establish more scientific policies of sustainable development.