In the base-knowledge economic age,as far as how to improve work efficiency of knowledge worker is concerned,this paper analyzes influential factors of work efficiency of knowledge worker on the whole,and classifies them into four sorts: individual factor,task factor,management factor,environment factor.The authors establish concept model in crucial influential factors according to interrelated theory of management and psychology.The interrelation and workable mechanism of influential factors are analyzed according to the characteristics of knowledge worker and individual behavior model on the bases of theory of achievement and motivation.The result shows individual factors affect work efficiency directly,task factor,management factor and environment factor which support and restrict individual factor indirectly affect work efficiency.