The monitoring and assessment scheme of the Caiyuanba Yangtze Bridge is present by sensitivity analysis. The mechanics character of the six ties is studied by numerical simulation, and then the sensor location and selection are discussed considering the technique of sensor and construction situation. The trend of the displacement at the sensor location is analyzed according to different damage level of ties, the pattern associating with several displacements which are sensitive to damage at ties is bring forward to improve assessment reliability. The result can assist implement of structural health monitoring system to the same type as this bridge.