Aiming at systems which are of characteristics of multi-input and multi-output, nonlinearity and time-variation in the industrial control fields, this paper presents a intelligent PID control method based on ameliorative RBF neural networks, which constructs RBF neural networks identifier on-line and identifies a controlled object on-line by means of adopting the nearest neighbor-clustering algorithm, and adjusts parameters of PID controller on-line and realizes decoupiing control of multivariable, nonlinear and time-variation system. The simulation result indicates that the controller can get parameters which are optimal under some control law, it makes the decoupled system, compared to the PID control method based on the conventional RBF neural networks, has perfect dynamic and static performances, possesses the advantages of high precision, quick response speed and is of great adaptability and robustness.