Though Ginkgo biloba extract(GBE)and ginsennosides(GS)also have notability bioactivity on cardiovascular disease,there is little literature about applying the compound of them to treat cardiovascular disease.After endothelium cells suffering from oxidative injury were treated with serum containing GBE,GS and the compound of them(GG),respectively,production of NO,ET and MDA in them was observed by applying serum pharmacology.Both GBE and GS up-regulate NO level and down-regulate ET-1 and MDA level in endothelium cells suffering from oxidative injury.Anti-oxidation activity increased after GBE and GS were combined.But the NO up-regulation of GG was inferior to that of GBE and GS,which decreased by 29.9% and 66.7% when compared with that of GBE and GS,respectively.The ET-1 down-regulation of GG was superior to that of GBE, but decreased by 11.6% compared with that of GS.The compatibility of GBE and GS do not show synergic effect on NO and ET-1 regulation in endothelium cells and it is valuable to discuss that the compound of GBE and GS is used to treat cardiovascular diseases.