There are complicated non-linear relations among influence factors, and between influence factors and decision - making results, which cannot be handled by common analytical method effectively. So the ANN technology was applied in the pre-bid decision-making processes. An indicator system of influence factors for pre-bid decision-making process was built based on extensive investigations, comparisons and analyses, with due considerations to the ANN analysis requirements. And then the criterion and method for quantifying the indicators were put forward by quantificational methods and fuzzy theories. An ANN model for pre-bid decision- making process was constructed and performed in Matlab, which has powerful learning ability and fast learning speed. The model was verified by a few examples from engineering practice.