Regional manufacturing information engineering industries are extremely large and complex systems. Based on the implemental integer effect and an evaluation requirement of regional manufacturing information engineering, we analyzed the objectives and characteristics of regional manufacturing information engineering, proposed a multiple evaluation index method of regional manufacturing information engineering. Based on a multiple integration evaluation method, we built a model to evaluate regional manufacturing information engineering. We proposed a measurement model for regional manufacturing information engineering based on multilevel fuzzy comprehensive evaluation. Our quantitative research regarding the implementation effectiveness of regional manufacturing information engineering was based on fuzzy quantitative indicators. The model was grounded on collecting indexes of regional manufacturing industry information engineering, and used a fuzzy matrix to normalize the assessment results to a single fuzzy comprehensive evaluation level. Measurement was carried out step by step. Multilevel comprehensive evaluation results for a regional manufacturing information engineering industry were obtained. The validity of the model was shown through application practice.