Synthesis and characterization of a new pHsensitive hydrogel
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Abstract:
A novel pHsensitive degradable hydrogel based on ethylenediaminetetraacetic dianhydride (EDTAD) was synthesized.EDTAD reacted with butanediamine through Nacylation ringopening polymerization of anhydride groups to give a linear copolymer (pEDTADBDA) with carboxyl groups on its side chains and amide groups on its backbone. pEDTABDA was dehydrated between those carboxyl groups on its side chains and amide groups on its backbone at 160℃ with phosphoric acid as a catalyst. A copolymer was produced containing imide groups (pEDTADBDAImide). pEDTADBDAImide was crosslinked by BDA via Nacylation of the imide groups, yielding the desired network polymer with pendant amino groups (BDAcrosslinkedEDTADBDA). BDAcrosslinkedEDTADBDA is a promising hydrogel for drug controlled release integrating such advantages as degradability, good biocompatibility and pHsensitivity. FTIR and ninhydrin reaction are employed to qualitatively and quantitatively characterize pEDTADBDA and BDAcrosslinkedEDTADBDA.
