Based on a spatial nonstationary model of seismic ground motion, the seismic acceleration time history are simulated by the wave superposition method. And then taking CaiYuanBa arch bridge in Chongqing as original model , this paper utilizes timehistory analysis method to analyze the seismic response characteristic of this type of longspan arch bridge by support consistent or multisupport seismic excitation .The numerical results indicate that the spatial variation of seismic ground motion have significant effect on the response of the arch bridge. Thrust of arch rib and vertical displacement, internal force of arch crown are increased greatly, but most internal forces of stiffener support are reduced.