A multipath interference cancellation RAKE receiver with nested structure is proposed based on successive interference cancellation method. In the proposed method, the present branch and the demodulated branch form a substructure of the RAKE receiver, while the RAKE substructures are nested. The data estimate of the present branch is obtained by the maximum ratio combination of the demodulator output in the corresponding RAKE substructure. The update of the regeneration signal is achieved by replacing the previous branch data with the present branch data estimate . Performance of the new RAKE receiver was analyzed. Theoretical analysis and simulation results show that the new RAKE receiver with simple structure and easy implementations can suppress the multipath interference and improves the BER performance.