This paper studies the landslide mechanism by the analysis of accumulation form, topography and geomorphology, self structure and natural river system of Weijiagou coal gangue hill. The limit state function is established based on plasticity mechanics limit analysis upper bound theorem and Bishop slices method, combining reliability theory. The safety coefficient and reliability index of Weijiagou coal gangue slope is calculated. The plasticity limit analysis upper bound theorem can consider the interior stressstrain relation of soil, so the formula derivation process is stricter. It is the consideration of the variability of gangue parameters that making the evaluation result more reasonable.