Expert’s decision process plays an important role in production systems. To simulate complex production system including expert decision, an intelligent simulation strategy of complex production system based on interactive simulation and knowledge mining is proposed. The simulation principles and methodology are described. Key technologies of expert decision process simulation are studied in detail from the aspects of simulating algorithm and software programming. The simulation strategy is used and verified in a universal rail production line. Simulation results indicate that the intelligent simulation model can effectively describe complex production system including expert decision. It provides a new method for humanmachine cooperation and human decisionmaking process study in production systems.