Parametric study with orthogonal experiment is carried out for digestion of municipal sewage sludge with H2O2 and H2SO4. For TN, the adding time of H2O2 is significant at 0.1 level, whilst the dosages of H2O2 and H2SO4 are less significant. The better digestion scheme is that the number of adding time of H2O2 is three and the dosages of H2O2 and H2SO4 are 0.25 mL and 1 mL, respectively. And for TP, the adding time of H2O2 is significant at 0.01 level, and the dosage of H2O2 is significant at 0.05 level. However, the dosage of H2SO4 is less significant. Thus, the better digestion scheme is that the adding time of H2O2is three and the dosages of H2O2 and H2SO4 are 0.25 and 5mL, respectively. Combining the two schemes, the optimal scheme of sludge digestion is three times for H2O2 adding and 0.25 and 5mL for the dosages of H2O2 and H2SO4, respectively. With the test, the recovery rate of TN is between 98.53% and 101.80%, while the recovery rate of TP is between 97.07% and 101.67%.