There is no effective integration between knowledge management and process management in current modern workshop management. In order to deal with the problem and optimize business process operation, a knowledge management operation mode for manufacturing process of workshop is proposed on the basis of analyzing knowledge management requirement, and the operation mode is analyzed in detail from four aspects, manufacturing business, knowledge resource, knowledge operation and relevant information systems. Some key technologies to realize the operation mode are studied, including semantic description of manufacturing process and knowledge representation based on ontology technology. Finally, a case study is provided and the feasibility and effectiveness of the operation mode are demonstrated.