To explore the characteristics of deformation of sandstone under cyclic pore water pressure, the experiments with different axial stresses (60%, 70% and 80% of peak intensity) of sandstone subjected to cyclic pore water loading are investigated by using MTS815 rock mechanics testing system, and irregular small deformation in deformation curve of sandstone are also processed by wavelet transformation of Matlab. The results show that with the increase of constant axial stress, fatigue deformation under cyclic pore water pressure will accelerate the failure of the sandstone. With the increase of the number of cyclic pore water pressure, the deformation evolution of the plastic-loop is illustrated as sparse-dense-sparse. The deformation curves of sandstone under cyclic pore water pressure affected by many factors are decomposed, reconfigurable processed and evaluated by using wavelet transformation, which indicates that the basic curve with optimal decomposition scale fits well with the experimental curves and reveals the deformation evolution of sandstone.