Three specimens of sandwich joints with eccentricity being larger than a quarter of the column width in middle floor of frame are designed and loaded under cyclic loading. Their shear capacity, failure modes, and ductility, as well as energy dissipation are analyzed. The results show that the performance of sandwich joints with big eccentricity is good under cyclic loading. X-type reinforcements can be used to substitute for stirrups in the joint to bear shear forces. But the anchorage of longitudinal bars of beams in eccentric sandwich joints is relatively weak. Comparing to sandwich joints without eccentricity, the column longitudinal bars near the sandwich joints with big eccentricity are vulnerable to sudden change of strain.