The technology of coal dust explosion suppression is an important means for coal dust explosionproofing. The core of this technology is to develop the inhibitor with effective explosion suppression performance. Firstly, the mechanisms of 3 inhibitors are analyzed, namely physics-based, chemical-based and mixture-based mechanisms. Secondly, the existing inhibitors are categorized and the basic property of the novel inhibitor is put forward. Then, the technology of synergistic mixtures is adopted to tap inhibitors by choosing 3 monomers (aluminum hydroxide, ammonium polyphosphate and diatomaceous earth) and synthesizing, and finally get 3 new inhibitors A, B and C. Utilizing 20 L spherical explosion test system, based on the index of parameters of explicability, the effect of the novel inhibitor is verified by explosion testing. The results indicate mixtures of inhibitors obtain good results, realize synergism and perform much better than traditional inhibitors.