Vehicle ignition system is the main electromagnetic interference source. Electromagnetic radiation produced by ignition system will produce the interference to electromagnetic environment around. It is necessary to study the electromagnetic interference (EMI) principle, noise paths and suppression method. We analyze the electromagnetic interference principle of ignition system, and harness trouble-shooting related to electromagnetic interference is also tested. Results show that the spark discharge between spark plug electrodes is the main interference source in ignition system. Then, the paths of conducted interference and the reason of radiated emission are discussed in detail. Finally, two kinds of power supply cord EMI filters are designed and implemented on the basis of analysis results. Experimental results indicate that the filter can reduce the noise of power-wire in broadband range. Simultaneously, the radiation emission performance from power wire is also reduced observably. The proposed mixing filter has been demonstrated in this paper to perform satisfactorily with excellent effectiveness in suppression of conducted EMI from 10 MHz to 110 MHz, and the object car can also pass the EMC standard tests.