In order to optimize the quenching parameters of ultra high strength steel 22MnB5,orthogonal experimental design method is applied to design the experiments and response surface methodology (RSM) is used to analyze the experimental results. Austenitizing temperature and soaking time are taken as the optimization factors. The effect of these factors on quenching hardness and elongation are investigated. The optimization results of each single objective are firstly obtained. Then,ideal point method is used to find the solution to the multi-objective programming,and global optimums are gained. Finally,the optimal results are discussed from the microstructure angle and the reliability of the prediction models is demonstrated.