Gas-filled coal permeability evolution tests are carried out before and after the long-term load with temperature and effective stress changing by using the triaxial permeability equipment. Based on the experiments，temperature sensitivity coefficient and effective stress sensitivity coefficient of the permeability of the coal sample are analyzed before and after the long-term load. The experimental results are shown as follows：1)Before and after the long-term load，with the increase of effective stress，the permeability and effective stress sensitivity coefficient both decrease when the temperature keeps constant. At the same time，with the increase of temperature，the permeability and temperature sensitivity coefficient also decrease when the effective stress keeps constant；2)The difference of the permeability between before and after long-term load is different with temperature and effective stress changing，and it reflects thermal-fluid-solid coupling effect；3) Before and after the long-term load，the difference of temperature sensitivity coefficient first increases and then decreases with effective stress increasing，and it becomes negative when the effective stress is about 4.3 MPa. What’s more，the difference of effective stress sensitivity coefficient will decrease with the temperature increasing，and become negative after 26 ℃.