The numerical analysis of a conventional aluminum alloy roof system taken from an actual international airport under wind uplift is conducted. A two-step simulation analysis approach is proposed, which effectively overcomes the computational difficulties brought by the contact between panels and supports. Through numerical analysis of roof components, the failure mode of the roof connection and the load bearing capacity of the roof are obtained. And the efficiency of material strength in each component is evaluated as well. It can provide reference for the design and application of aluminum alloy roof structure.