Existing pipeline safety evaluation models commonly use the subjective methods such as the expert evaluation method, but the subjective consciousness has serious influence on the determination of index weight. Therefore, the match degree of the evaluation and the real condition is low and the evaluation result lacks of comprehensiveness. This paper determines the major evaluation index of long-distance oil-gas pipelines through the analysis of the goals and features of the safety evaluation. Fuzzy mathematics method is applied to build the comprehensive evaluation model of long-distance oil-gas pipelines and to analyze the key technology of the evaluation model. Variation coefficient method and analytic hierarchy process are comprehensively utilized to make a quantitative analysis of the criteria layer weight, and preferential relation matrix and fuzzy consistent matrix are established to determine the index layer weight. Finally, some examples are given to verify the feasibility and accuracy of the proposed model.