To adapt to the rapid changes of manufacturing environment,production cell needs to focus on high qualified staff and flexible human-machine cooperation method at the same time,when advanced manufacturing technology(AMT) is emphasized on. In order to study human-machine cooperation strategy dynamically and quantitatively in production cells,a simulation study which combined computer simulation with agent modeling technology is carried out. Firstly,a human-computer cooperation simulation model is established,and its realization method is presented. Secondly,specific cooperation mechanisms of designated production cell cooperation,partly independent cooperation and completely independent cooperation are studied respectively. Finally,an engine production cell is taken as an example,a series of simulation experiments are designed,and four performance indicators of the task waiting time,order on time percentage,waiting rate of machine and operator utilization are established to analyze and evaluate all kinds of man-machine division modes of the production cell to find a more reasonable mode.