Through lots of screening tests, two fume suppression agents, i.e. SBS and nanometer CaCO3, which can reduce the asphalt fume without affecting the properties of asphalt, are screened from seven additives. The best ratio of two agents for suppressing fume is presented by contrast tests of fume suppression effect, and the fume can be reduced about 30%. The properties of asphalt concrete with fume suppression agents and the mechanism of SBS and nanometer CaCO3 reducing the asphalt fume are investigated. The research findings are useful for reducing the asphalt fume in bad ventilation condition of channel pavement and urban road pavement construction.