MicroRNAs (miRNAs) are a class of short non-coding RNAs of 18 to 24 nucleotides in length that post-transcriptionally regulate various target genes which involving in a variety of biological processes such as cell cycle，differentiation，cell proliferation，and apoptosis.At the transcriptional level，transcription factors (TFs) has been considered as the primary regulator to control the gene expression.Recent studies show that transcription factors regulate the expression of miRNA，and participate in a variety of biological processes including tumorigenesis.The regulatory network of TF-miRNA has been studied widely，and this paper reviews the recent research findings.It’s hoped to provide a theoretical basis for study of regulatory pathway of TF-miRNA in the future.