In order to solve the incipient fault diagnose problem of the transmission system, a networking condition monitoring and failure diagnosis system based on B/S and C/S hybrid architecture for wind turbine transmission system is designed in the paper. Firstly, the paper analyzes the demands of condition monitoring and fault diagnosis system for wind turbine transmission system, and designs its overall framework and function modules. Then, combining with the data acquisition equipment, by the .NET and SQL Server platform, the paper designs condition monitoring and failure diagnosis system for wind turbine transmission system, which includes the functions of networking data acquisition, remote condition monitoring, signal analysis, fault diagnosis and database as well. The system has been successfully applied to a condition monitoring and fault diagnosis of wind turbine transmission system.