In order to fully research the effects of external excitations, such as wind speed, wind direction and voltage disturbance, on a grid connected wind turbine with doubly fed induction generator, a co-simulation model of MW-class wind turbine system is established by using Simpack and Matlab/Simulink software. Also, by considering the actual control strategies in the process of simulation, the relationship between external excitations and mechanical system is studied. According to time-domain simulation under the turbulent wind condition, the dynamic meshing forces of gears are analyzed. Besides, the vibration responses of tower are calculated under the different external excitations. Research results lay a foundation for dynamic performance optimization and reliability design of a wind turbine.