Automobile is a man-machine coordinate-controlled complex system.Based on NI PXIe8108 real time controller and related hardware and software, a driving simulation system is built.Also LabVIEW programming language is used to build a vehicle dynamics model and unity 3D virtual technology is used to build driving scene. By using database method, data exchange between driving scene and simulation process is realized.Results show that importing driver’s control in simulation process realizes human-in-the-loop and human-machine interactive simulation.Automobile simulation results are obtained in driving simulation environment, which makes it possible to do human-automobile coordinated control experiment in safe and reliable way.