The Guanyinxia anticline is a typical layered thermal reservoir, and 11 geothermal wells have been successfully implemented in its southeast flank. Using comparative study, correlation analysis and other methods to analyze the data of these wells, we research the enrichment characteristics of the geothermal water in typical layered thermal reservoir. The results show the larger the thermal reservoir buried depth is, the weaker the karst development and the poorer the geothermal water is. While, the larger the thermal reservoir buried depth is, the better the heat insulation performance of the thermal reservoir and the higher the temperature of hot water is. The thicker the layered thermal reservoir is, the stronger the karst development and the richer the geothermal water is. While, the thicker the thermal reservoir and the stronger the karst fissure's development is, the lower the temperature of hot water is. The layered thermal reservoir with gradually changed occurrence is relatively rich, and the average water yield of the geothermal wells is 2 136.75 m³/d, while the layered thermal reservoir with rapidly changed occurrence is relatively poor, and the average water yield of the geothermal wells is 584.93 m³/d.