Brain control is a new man-machine control method using electroencephalogram (EEG) and electromyography (EMG) to control the device. In order to facilitate its multi-device integrated control system construction, a design of a new compatible multi-device control signal interface is presented. Meanwhile, its working principle of three-tier structure, work processes in different modes and hardware design of the functional modules are described in detail. By ways of display feedback and confirmation alert, the interface also includes a security function, which can effectively improve the safety control system.