Equipment selection and thermo-economic evaluation have great influence on thermodynamic performance, economic feasibility and environmental impacts of ORC (organic rankine cycle) systems. Selecting R123 as working fluid, we conduct the main parameters of equipment and thermos-economic analysis for ORC electricity generation system driven by the flue gas waste heat of a real 30 t/h industrial boiler. Then heat exchanger sizes and thermos-economic results are calculated, and the operating parameters of equipment and heat exchanger layout are put forward. The results show that the unit capacity cost, electricity production cost, payback period, net power output and electricity production power are 23 800 Yuan/kW, 0.285 Yuan/(kW·h), 5.58 years, 91.5 kW and 88.5 kW, respectively. Considering the main equipment and operation maintenance cost, the system total investment is RMB 3.45 million.