The continuous girder bridge with new high piers of Concrete Filled Steel Tubular (CFST) laced column has a broad prospect in the construction of bridges in earthquake area. Based on the engineering background of Gan haizi super-large bridge, 34 finite element models of three span continuous bridge were built by universal program of Midas Civil, with different structure design parameters including the pier height, longitudinal slope, axial compression ratio, diameter ratio of lacing tubes and longitudinal tubes, vertical spacing of flat lacing tubes, steel ratio of longitudinal element, number of bracing element, pier top spacing and section form of longitudinal element etc, and the influence of structural parameters on seismic performance of continuous girder bridge with high piers of CFST laced column and the application scope of these parameters were researched through elastic seismic response analysis on E1 earthquake. Then, optimum design of bridge was carried out on the base of numerical results, and calculation results indicated that seismic response of optimized model reduced greatly.