The numerical analysis results of staircase, based on the finite element software of ABAQUS, are compared with the experimental results to verify the applicability of finite element parameters and modeling method. On this basis, 2 groups of reinforced concrete(RC) high-rise frame models are established to perform dynamic time-history analysis in two circumstances:the adoption of cast-in-place resistant connection and that of prefabricated slip connection. Multiple aspects are adopted to research the influence of each modeling method on structural seismic performance, including the displacement response, the plastic damage evolution and the seismic response. And the seismic performance of multi-storey and high-rise models are compared. The analysis results are as follows. Cast-in-place resistant connection causes larger displacement, aggravates the torsion effect, causes severe stress concentration and amplifies the seismic effect, which ultimately leads to seriously structural damage and tension or compression failure. Prefabricated slip connection has smaller displacement, more homogeneous stress distribution and slighter damage of members, which can ensure that the stairways are reserved as safe passage after an earthquake; therefore, prefabricated slip connection performs better in terms of the displacement response, the stress damage and the seismic response than cast-in-place resistant connection. Compared with multi-storey model, the high-rise model has more severe seismic results in the whole stress, plastic development, damage range and severity, which makes it behave better in slip effects.