In the narrow and long open-pit mine of inclined coal seam, the mining procedure of vertical mining and horizontal mining are often adopted. In view of the influence of the change of the distribution of logistics on the economic reasonable stripping ratio, the block system optimization by stages was proposed, which involved two patterns, namely A pattern (the first mining area was located in the right side of the mining right) and B pattern (the first mining area was located in the middle of the mining right). In addition, the process of mining was divided into three periods according to the change of the separation of logistics to the flow:all external drainage, partial internal drainage and total internal drainage. By constructing the location model of stripping, mining and drainage, the paper systematically studied the principle and the conditions applicable to the state optimization of two mining modes, and put forward the model of state optimization. The research was applied in the practice of the Zhundong surface coal mining and the results show that the economic stripping ratio has increased from 1.50 m³/t to 1.62 m³/t, the economic mining depth by 24.7 m, the overtopping distance by 45.65 m and the economically recoverable reserves by 85.27 Mt, realizing the economic interest maximization of open-pit mining.