The seismic performance of frame-shear wall structure on the slope under frequent and rare earthquake was analyzed through a number of calculating examples with different floors and two fixed ends of the core shear walls. The effect laws of different fixed ends of the core shear walls for the shear distribution and seismic performance of the upper and lower grounding parts of the structures were discussed. It is found that the shear distribution of the upper and lower grounding parts of the structure is extremely uneven. The shear force ratio transmitted by each grounding part is affected by number of layers and the fixed end of the core shear wall. Selecting the fixed end of the core shear wall can coordinate the unevenness of shear transmission to some extent, and when there are a number of layers, it is more reasonable to embed the core shear wall on the upper ground, while when there is only a small amount of shear wall at the upper ground, plastic deformation is liable to be concentrated, and the design should focus on the ductility of such components.