In order to solve the existing problems in the practical engineering design method involving the second-order effect of staggered frame structure, by combining with The Concrete Structure Design Codes and through theoretical analysis and the example comparison, this paper proposed some feasible methods to simplify designation. The methods well reflect the law of the second-order effect of staggered frame structure, and it can be used to guide engineering design and to provide reference for regularizing the relevant provisions revision and subsequent research work.