In the process of coal gasification, there are many kinds of raw materials and products that are inflammable, explosive, poisonous and harmful, which can cause casualties and property losses. In order to evaluate comprehensively the risk level of safety production in coal gasification enterprises, we used the fuzzy comprehensive evaluation theory and selected the coal-to-methanol process, which is a typical coal gasification process, in a coal gasification enterprise in Chongqing as the study object to construct a reasonable indexes system of safety risk evaluation, and carried out fuzzy comprehensive safety evaluation of the enterprise.