Sandwich structures with excellent mechanical properties and multifunctional potentials can be applied as favorable impact protective structures. Low velocity impact resistance of woven fiber reinforced polypropylene honeycomb sandwich panel was experimentally studied using drop weight tester. Effect of impact energy on structural response under four sides fixed condition was investigated by changing drop height. Under the same impact energy, the effects of core height and core layer number on the impact resistance were also studied. Finite element model of honeycomb sandwich panel subjected to low velocity impact was established by ABAQUS and compared with experimental results in terms of load-time curves and failure modes. It was found that local depression of upper face sheet and core collapse were the dominate failure modes and a significant rebound of honeycomb sandwich panel was found when face sheet was not penetrated.