FEFLOW numerical simulation software was employed to simulate the dynamic changes of groundwater of Hankou district, Wuhan. The regional model was used to provide boundary conditions for Erqi business district so as to construct the refined model of groundwater dynamic change in the studied area. The highest water level of confined aquifer got by simulation was 27.5 m around the flood control wall of the Yangtze river in the east of business district. The groundwater level gradually decreased from east to west, and finally dropped to 22.0~25.9 m within the business district. The research results can provide reasonable anti-floating fortification water level for anti-floating design in the area, furnishing the basis for accurate calculation of groundwater buoyancy.