Using a multi-purpose transmission friction test bench, variable-speed dry friction tests were conducted on lip-type oil seals composed of fluoroether rubber, with considering different interference levels and media-aging durations. The effects of aging time and interference on spindle torque, vibration, and frictional wear were systematically analyzed. Results show that, within the tested parameter range, spindle torque decreases with prolonged aging time, while vibration initially decreases and subsequently increases. Increasing interference leads to higher spindle torque and vibration. Moreover, longer aging time and lower interference correspond to reduced wear of the oil seal. Surface observations further indicate that extended aging time produces smoother frictional surfaces and more pronounced swelling.