The paper analyzes the positive role of treasury single account system in the field of formulating financial system,sums up changes in the financial management of colleges and universities with the effect of treasury single account system and generalizes the problems existing in the implementation of the treasury single account system. The writer suggests that we could make the budge detailedly, reinforce communications, establish the internal control system, and build up rules and regulations of financial management fitting in with the treasury single account system, and then we can drive financial management of colleges and universities to the direction of the fine management.