To meet the requirement of building environment and equipment engineering (BEEE) teaching, the paper proposed principles and methods of comprehensive course design reform and construction of BEEE.The course design should follow principles of systematicness, comprehensiveness, openness and innovativeness.The paper also compared the comprehensive course design with the traditional single course design, and showed that the course design should be comprehensive in design content, design methods, implement subject, guiding ways and assessment methods.To effectively carry out the comprehensive course design, some preliminary measures and provisions should be gradually built, such as the curriculum system construction, teacher quality improvement and the assessment system, which can enhance the teaching effect, improve students’ study and application abilities, and realize the goal of applicationoriented talent training.