The specialty construction is the core of connotation construction in colleges and universities, which has a profound impact on reform and development of colleges and universities. How to guide the development of colleges and universities using the external quality assurance so as to adapt to employment, economic and social needs, and how to highlight the specialty, professional quality of personnel training, we should not only focus on the undergraduate teaching quality monitoring system in the college, but also strengthen then external supervision and guidance. We researched on specialty construction in colleges and universities of Shaanxi Province, proposed how to construct quality guarantee system for the specialty construction in colleges and universities, and formed a quality guarantee system at the provincial level for the whole process of new degree declaration, degree granting, specialty evaluation and specialty authentication. Empirical research on the quality guarantee system was also carried out.