Based on the environment and internal factors affecting the development of department of civil engineering in Dongguan University of Technology, we analyzed the influence of region and administrative relation on characteristics to run a school and proposed the influence of talent training, specialty/subject construction, course system, teacher quality, scientific research, experimental base construction, and system administration on the sustainable development of specialty. The practice shows that only prompting each work in department of civil engineering based on development strategies and reality can realize the sustainable development of college guiding principles and the department of civil engineering.