The graduation design is the most important personnel training practice teaching link of universities and colleges, which tests students’ knowledge and comprehensive abilities. Based on the CDIO concept, we took the idea of large-scale engineering and life cycle as the main line and presented team graduation design content of the training mode on the basis of interdisciplinary and professional comprehensive knowledge. The guidance system combined the teaching of enterprise mentors and tutors, focusing on training students’ engineering, teamwork, communication and coordination abilities and their innovation spirit, to promote the quality of graduation project of civil engineering constantly. The research results provide a reference to the reform of talents cultivation in higher engineering education.