Specialized courses are important in cultivating engineering talents. Therefore, constructing a teaching structure in accordance with the characteristics of specialized courses is the requirement of deep teaching reform. Taking water regulation course of harbor and channel engineering specialty as an example and based on current teaching situation investigation, the teaching conception of the course was presented, the teaching structure titled "leading and the man body" was proposed, and the teaching experience was concluded. The "leading and the man body" teaching structure focus on teachers' leading role as well as students' cognitive subject status which can meet the teaching requirements.