Pollution control of indoor air is a special course of the building environment and energy application engineering specialty. It contains various and comprehensive knowledge. Thus, it is difficulty to teachers’ teaching and students’ studying. Analysis method of principal contradiction is used in this paper. Firstly, the teaching content of the course are optimized and the teaching emphases and difficulties are found. Secondly, in the course teaching, explaining is the main teaching method. Discussion, cases and experimentation are accessorial teaching methods. The basic knowledge, principle and conception are explained intensively. The result shows that students’ positivity is excitated and they can obtain and apply knowledge in practice.