The paper analyzes the interactive relationship between talent training, scientific research, social services and cultural inheritance innovation. Then it studies the implement path of cultivating talent in local application-oriented universities as the example of Anhui Jianzhu University. It suggests that local application-oriented universities should find the right orientation, play the comparative advantage, carry on the dislocation development, and format the characteristics. Local application-oriented universities should improve the talents training quality with cultivating application-oriented talents, strengthening the scientific research and social services in characteristic fields and forming the local characteristic culture education teaching system.