The postgraduate course of building safety technology has been set in civil engineering discipline of Beijing University of Technology according to the requirements of city building fire safety technology and development of subject research field. Based on the characteristics of this course and different knowledge background of students, the teaching reform on interdisciplinary knowledge has been taken. Probe on course contents selecting, teaching methods, teaching evaluation, strengthening the connection between theoretical and practical engineering has been carried out. It has been found that teaching reform can stimulating student’s interest in learning process, improving the effect of teaching and enhancing the capabilities of scientific research.