Development of the university cannot be separable form the push of the reform. Since the nineteen seventies，Harvard University has experienced three comprehensive major reforms and these reforms promoted the great leap forward development of Harvard University,made the Harvard University gradually into the world first-class university, and eventually become the paradigm of the world first-class university. Although China have different national conditions, history and culture are different, but the basic characteristics of these successful reforms have enlightenment and reference significance on the contemporary comprehensive reform of Chinese University.